Autoimmune Research

Key players in the body’s defenses, macrophages are immune cells that swallow bacteria, viruses or infectious germs. When the body comes under attack, these white blood cells engulf the attackers and eliminate the threat. Like characters in a Pac-Man video game, they roam the body,...

Early in her career, pediatric rheumatologist, Tiphanie Vogel, MD, PhD, cared for a seven-year-old boy with a rare form of juvenile arthritis (JA). She discovered that her young patient had a specific genetic mutation that damages multiple organs and severely affects the joints. Dr. Vogel, an...

Autoimmune diseases arise when the immune system turns on itself, triggering an inflammatory response that destroys the body’s own tissues. Rheumatoid arthritis (RA) erupts when the immune system, which normally protects against infection and disease, instead attacks the joints, causing swelling, stiffness and crippling pain. With...

Psoriatic arthritis - an aggressive and joint-destroying inflammatory disease - arises when the immune system mistakenly attacks the body’s own tissues. When the flawed immune response kicks into overdrive, rampant inflammation triggers crippling joint pain, stiffness and swelling. Not to mention that painful and persistent...

Rheumatoid arthritis (RA) is a chronic inflammatory disease that attacks cartilage and bone, progressively destroying multiple joints. In the hope of finding a cure, researchers are looking at a genetic mechanism in rheumatoid arthritis by scrutinizing gene mutations that kindle autoimmune diseases. Rheumatoid arthritis, a...